Synthetic Salusins as Cardiac Depressors in Rat
نویسندگان
چکیده
منابع مشابه
Synthetic salusins as cardiac depressors in rat.
Using bioinformatic analyses of full-length, enriched human cDNA libraries, we recently identified salusins, multifunctional related peptides ubiquitously expressed in major human tissues. Salusins cause transient and profound hypotension when injected intravenously to rats, the hypotensive effect of salusin-beta being especially striking. However, the mechanisms of this hypotensive action rema...
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Human salusin- α and salusin- β are related peptides produced from prosalusin. Bolus injection of salusin- β into rats induces more profound hypotension and bradycardia than salusin- α . Central administration of salusin- β increases blood pressure via release of norepinephrine and arginine-vasopressin. Circulating levels of salusin- α and salusin- β are lower in patients with essential hyperte...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2005
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000156496.15668.62